1. or more than normal numbers of platelets.

1.     The
main purpose of the article is to provide background information about platelet
production, including how platelets were first discovered, the principles of
platelet physiology and principles about thrombopoietin, and these principles
have been used in a model to analyze the diseases involving platelet production
and alterations to it.


2.     What do you think is the most important
information in this article? If applicable, please indicate an important point
from each section of the article.

A person’s platelet count
stays relatively constant with normal values ranging from 150 to 450, and with
a maximum variation of 10% over time, but platelet counts can differ between
people. Platelet count is inversely proportional to the number, size, and
ploidy of the bone marrow megakaryocytes. It is also inversely proportional to
the mean platelet volume, and these two values multiplied together, along with
corrections taken into account, make up the platelet mass. The platelet mass
remains the same even if there are less than or more than normal numbers of
platelets. Regulation of the production of platelets is the responsibility of
Thrombopoietin (TPO) TPO binds to megakaryocytes to increase their number,
size, and ploidy. Platelet count and TPO are inversely and expontential
proportional to each other. It takes 24 hours for TPO to rise to the maximum
level with a sudden decrease in platelet count. TPO’s half-life in circulation
is less than 45 minutes, as they are removed from circulation by the platelet
mass. Platelets have TPO receptors which allow them to bind, ingest, and
degrade TPO, thereby removing it from circulation. The production rate of
platelets and TPO levels are inversely proportional. Platelet production issues
can manifest as the result of alterations to TPO, its receptors, or the
platelet mass and its ability to remove TPO from circulation.


The main
conclusion/s in this article is/are? The main conclusion in this article is
that platelet production is a complex process is regulated by thrombopoietin.

The principles of the physiology of platelets and thrombopoietin have been
incorporated in a model that has been used study diseases involving platelet
production, but there is still more about platelet production to be researched
such that the diseases affecting it can be treated, managed, and/or prevented. 44


The key
concept(s) we need to understand in this article is/are? The key concepts
to understand in this article are that platelets are made from megakaryocytes
in the bone marrow, and their production is regulated by thrombopoietin (TPO). The
principles of the both platelet physiology and TPO physiology are applied to
the model of platelet production that can be used to understand the many
diseases in which platelet production is impacted. 57


What is/are
the implication(s) of the article? The implications of the article are that
there is much already known about platelet production and of its regulator
thrombopoietin, but more research can and needs to performed to learn more
about the process and how it is impacted by diseases. Through further research,
more information about platelets and their production can be uncovered, and diseases
affecting platelet production can be better understood, treated, and possibly
even cured.


How does this article contribute to your current knowledge of the subject?

felt that this article helped improve my understanding of platelet production,
including the role of thrombopoietin, as well as how platelets exist and
function in our bodies. I feel I now know more about some of the diseases and
pathological conditions that impact people, and more importantly how these can
come about as a result of alterations to platelet production.