1. or more than normal numbers of platelets.

1.     Themain purpose of the article is to provide background information about plateletproduction, including how platelets were first discovered, the principles ofplatelet physiology and principles about thrombopoietin, and these principleshave been used in a model to analyze the diseases involving platelet productionand alterations to it.  2.     What do you think is the most importantinformation in this article? If applicable, please indicate an important pointfrom each section of the article.A person’s platelet countstays relatively constant with normal values ranging from 150 to 450, and witha maximum variation of 10% over time, but platelet counts can differ betweenpeople. Platelet count is inversely proportional to the number, size, andploidy of the bone marrow megakaryocytes. It is also inversely proportional tothe mean platelet volume, and these two values multiplied together, along withcorrections taken into account, make up the platelet mass. The platelet massremains the same even if there are less than or more than normal numbers ofplatelets.

Regulation of the production of platelets is the responsibility ofThrombopoietin (TPO) TPO binds to megakaryocytes to increase their number,size, and ploidy. Platelet count and TPO are inversely and expontentialproportional to each other. It takes 24 hours for TPO to rise to the maximumlevel with a sudden decrease in platelet count. TPO’s half-life in circulationis less than 45 minutes, as they are removed from circulation by the plateletmass.

Platelets have TPO receptors which allow them to bind, ingest, anddegrade TPO, thereby removing it from circulation. The production rate ofplatelets and TPO levels are inversely proportional. Platelet production issuescan manifest as the result of alterations to TPO, its receptors, or theplatelet mass and its ability to remove TPO from circulation. 3.    The mainconclusion/s in this article is/are? The main conclusion in this article isthat platelet production is a complex process is regulated by thrombopoietin.The principles of the physiology of platelets and thrombopoietin have beenincorporated in a model that has been used study diseases involving plateletproduction, but there is still more about platelet production to be researchedsuch that the diseases affecting it can be treated, managed, and/or prevented. 44 4.    The keyconcept(s) we need to understand in this article is/are? The key conceptsto understand in this article are that platelets are made from megakaryocytesin the bone marrow, and their production is regulated by thrombopoietin (TPO).

Theprinciples of the both platelet physiology and TPO physiology are applied tothe model of platelet production that can be used to understand the manydiseases in which platelet production is impacted. 57 5.    What is/arethe implication(s) of the article? The implications of the article are thatthere is much already known about platelet production and of its regulatorthrombopoietin, but more research can and needs to performed to learn moreabout the process and how it is impacted by diseases. Through further research,more information about platelets and their production can be uncovered, and diseasesaffecting platelet production can be better understood, treated, and possiblyeven cured.  6.    How does this article contribute to your current knowledge of the subject? Ifelt that this article helped improve my understanding of platelet production,including the role of thrombopoietin, as well as how platelets exist andfunction in our bodies.

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I feel I now know more about some of the diseases andpathological conditions that impact people, and more importantly how these cancome about as a result of alterations to platelet production.