Orphenadrine hydrochloride is used to treat Parkinsonism. It is
important to differentiate between Parkinson’s Disease and Parkinsonism.

Parkinsonism is a blanket term that encapsulates a variety of neurological syndromes
that can manifest themselves with symptoms similar to Parkinson’s Disease, namely
slow movement (bradykinesia) tremor, rigidity, and postural instability. There
are a variety of disorders that fall into this category, and since the symptoms
are similar to those that present in a patient with Parkinson’s disease, it is hard
to diagnose the individual on the basis of this similarity. Parkinson’s
Disease, on the other hand is a degenerative CNS disorder that affects
movement, and is normally irreversible, with treatment focusing on reducing symptoms.

On the other hand, treatment of conditions that result in Parkinsonism with a
drug such as orphenadrine hydrochloride may improve or result in the
alleviation of symptoms