As also observed and it did not support

As shown above from the
literature collected in this systemic review, maternal high-fat diet in-utero
does effect the neurobehavioral development of the offspring.  Most of the researches concentrate on the
body weight of the offspring and how it is a reflection of the poor maternal
diet.  This paper discuses the
relationship of the stress hormone with a high-fat diet, however not enough
research is available to conclude excess cortisol leading to possible substance
abuse in alcohol or nicotine.  The
relationship between oxytocin and sucrose was also observed and it did not
support or refute the hypothesis.  This
specific study illustrated that oxytocin did inhibit sucrose feeding, however
there was no indication that these offspring exposed to high sucrose in-utero
were susceptible to substance abuse.  Overall,
this paper examines how the mesocorticol and mesolimbic pathways are altered in
offspring exposed to high-fat diet in-utero. 
These pathways were examined via the measurements of dopamine and
dopamine transporters available in the reward centers of the brain.  These reward centers consisted of the
hypothalamus, amygdala and nucleus accumbens. 

            There has been a rise in substance abuse among the young
adult community.  These preclinical and
clinical studies allow for a further understanding of addiction.  Addiction is a deadly disease and can be
passed on to the next generation if not addressed and treated
appropriately.  To understand the root of
the problem and where in the brain it is affected, many pharmacological or more
effective behavioral therapies can develop to save the youth and future
generations.

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