CHD is a disease which causes a build-up of fatty plaque in the coronary arteries. The article selected aims to evaluate the hypothesis whether high plasma triglyceride levels and high HDL cholesterol levels can lead to the identification of elevated hypertension and insulin resistance as well as cardiovascular disease risk profiles such as CHD (coronary heart disease). Results were obtained from 2003-2012 involving 855 women (between the ages 17-51) and 453 men (between the ages of 16-52). The individuals were sectored into high and low risk groups. If one was placed in a high-risk group this would indicate they were more at risk of developing CVD. The diagnosis of forming CVD risk factor profiles used is called MetS1.
This was an effective aspect to the study as it gave a concise outcome in normotensive and hypertensive subjects. These were then subdivided into low and high-risk groups based on the triglyceride/HDL cholesterol ratio or from the MetS diagnostic criteria formulated. To measure the blood pressure of the selected men and women, the systolic and diastolic blood pressure was taken using a mercury sphygmamometer1. An average was then calculated and results were recorded (external variables were considered). In order to measure the HDL cholesterol levels individuals were instructed to fast 12 hours overnight.
The results obtained depicted a strong positive correlation between high HDL cholesterol and triglyceride ratio with elevated blood pressure levels (133/353=38%) in comparison to the rest of the findings (138/574=24%)1. CVD risk factors were seen to be considerably worse in two groups which were high HDL cholesterol ratio in comparison with low triglyceride/HDL cholesterol ratio. The results also portrayed that a positive diagnosis for MetS lead to more adverse cardio metabolic risk profiles. However, one could state that a change in HDL cholesterol levels doesn’t indicate a casual role in the development of CVD but due to alternate factors.
When a follow up study was conducted 10 years post previous analysis involving 6343 subjects, 51 CVD cases were identified with 31 non-fatal and 8 fatal coronary events. All these cases were seen to be at a high-risk group. Electrocardiographic evidence of individuals with high blood pressure lead to depict greater risk of ischemic heart disease. Thus, 25% of presumable healthy individuals were more resistant to insulin therefore deciphers a greater risk of CHD.
1 Thus, as a result, the study provides both clinical and pathophysiological information to determine a relationship between elevated hypertension and HDL cholesterol with a type of CVD being CHD. Healthy individuals displaying a cardio metabolic risk profile had an increased risk of CVD when determining their plasma concentration ratio of triglycerides/HDL cholesterol. Hence, would lead to elevated hypertensive levels and at a greater degree of risk of development of CVD. Resultantly, basic lifestyle alterations such as dietary stipulations of fats as well as weight reduction or drug therapy can lead to lowering the risk of high blood pressure.
1. As for cholesterol, potent cholesterol lowering drugs such as statins can reduce the risk of developing CHD in later life.2.