I student of Masters in Biochemistry at University

I am writing this to express my great interest in applyingfor the PhD program in your research group.

I am a student of Masters in Biochemistry at Universityof Hyderabad, India. As a part of my curriculum I am pursuing my Mastersproject in Anil Kumar’s Lab at Universityof Hyderabad, India I went through your institute’s website and having reviewedthe international PhD program run by the institute, I believe that I am a capablecandidate and would like to apply. I have always been interested in the studyof cancer biology and due to my interest I have a fair level of textbookknowledge in the field. I would like to pursue my research in the field ofcancer biology and make it as my career in the long termDue to my interest in biology, I opted for Bachelors ofsciences with Microbiology as my major subject and chemistry and zoology as mysubsidiary subjects.

Throughout my coursework I was exposed to many subjectssuch as cell biology, biochemistry, genetics, immunology, molecular biology andfermentation technology. This exposure in the field of biochemistry and theconstant motivation received from my biochemistry teacher motivated me topursue my career in research. This led me to take admission in Masters inBiochemistry at University of Hyderabad.I started my Masters course from July 2016 where I wasexposed to courses such as Metabolism, Genetics, Human Physiology, Biophysics,Molecular Biology, Cell Biology, Enzymology and Immunology.

Apart from theorycourses we were trained in various biochemical techniques. In my third semesterI joined Lab of Investigative Nephrology in our Department for my one yearMasters project titled “MethylglyoxalInduces Epithelial-Mesenchymal transition in Podocytes: Implications inDiabetic Nephropathy”. Methylglyoxal is elevated during diabetes and isknown to enhance production of Advanced Glycation End-Products. The team haddiscovered that methylglyoxal induces NF-?B pathway. My work is to exposepodocytes to methylglyoxal and through Western blot analysis and Real time PCRanalysis find out whether methylglyoxal induces EMT in podocytes. The futuregoals are to investigate the possible mechanism by which methylglyoxal inducesEMT.

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This project has brought me close with study of different signalingpathways that induce EMT. During this project I have gained hands on experiencewith mammalian cell culture, RNA & DNA extraction, Protein extraction,Western Blot Analysis, Real time-PCR analysis.Due to my interest in study of different signaling pathwaysand cancer research I opted for Signal Transduction and Phosphorylation andCancer biology elective courses offered by the Department of biochemistry.These courses helped me develop an in depth knowledge about these topics. Ifind that the research going in your lab suits my interest as well as myeducational background. After going through your website I understand that yourlab uses a very interdisciplinary approach to gain more insights in mechanismsof cell growth. Understanding how the connecting pathways that regulate cellgrowth are altered and what sort of genetic program directs these changes couldbe really helpful in understanding the acquired capabilities of cancer cells.

 Pursuing my PhD in such an environment wouldbe the best choice in my academic pursuits. I believe that I am hard working,motivated and sociable person. My future goal is to join a reputed universityas a faculty member or become a post-doctoral fellow. To accomplish my goals, Iwould like to pursue my research leading to a doctoral degree in aninternational and multidisciplinary environment. I am looking forward toundertake my research towards a doctoral degree at the German Cancer ResearchCenter, Heidelberg. I would be very grateful to you if you could provide somemore information about your current research goals.I am looking forward to hear from you Yours SincerelyRuchika KumariThanks for helping!